Medicine

Accelerating ASO treatments from advancement to application

.Contending interests.R.S., M.S., H.G. as well as A.A.R. are actually organizers of the 1M1M initiative. H.G. and A.A.R. are actually board of supervisors members and R.S., M.S. and A.A.R. are actually participants of the medical advising committee of N1C. A.A.R. makes known employment by LUMC, which has licenses on exon-skipping modern technology, some of which has actually been actually accredited to BioMarin and also ultimately sublicensed to Sarepta. As co-inventor of a few of these licenses, A.A.R. was entitled to a share of nobilities. A.A.R. further discloses serving as specialist for PTC Therapeutics, Sarepta Therapies, Regenxbio, Dyne Therapies, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco and also Astra Zeneca. Before 5 years, A.A.R. additionally performed speaking to for Alpha Anomeric. A.A.R. likewise discloses membership of the medical advisory boards of Eisai, Hybridize Therapeutics, Silence Therapies, Sarepta Rehabs, Sapreme as well as Mitorx. In the past 5 years, A.A.R. was actually likewise a scientific board of advisers member for ProQR. Pay for A.A.R. u00e2 s consulting as well as recommending tasks is actually paid out to LUMC. Over the last 5 years, LUMC additionally got audio speaker honoraria coming from PTC Therapies, Alnylam Netherlands, Italfarmaco and Pfizer and also moneying for arrangement investigation from Sapreme, Eisai, Galapagos, Synaffix and Alpha Anomeric. Project funding is actually acquired coming from Sarepta Therapeutics as well as Entrada through unlimited grants. H.G. possesses nothing to divulge in connection with the subject matters dealt with within this composition. Over the last 5 years, he has actually additionally gotten consultancy honoraria coming from UCB. M.S. obtained working as a consultant gratuity coming from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly and also Solaxa before 5 years, all unrelated to the here and now composition. R.S. possesses nothing to divulge in connection with the subject matters covered within this composition. She has acquired sound speaker and/or working as a consultant gratuity or sponsoring additions from Abbvie, Bial, STADA and Everpharma before 5 years.